This paper presents a feasibility study of a wearable computing system to protect construction workers from carbon monoxide poisoning. A pulse oximetry sensor has been integrated into a typical construction helmet to allow continuous and noninva- sive monitoring of workers’ blood gas saturation levels. To show the feasibility of monitoring for carbon monoxide poisoning without subjecting users to dangerous conditions, a prototype for moni- toring blood saturation was constructed and tested during a user study involving typical construction tasks to determine its re- liability while undergoing motion. As monitoring for and CO simply differ in the number of wavelengths of light employed, if monitoring is feasible, then monitoring for CO will be feasible as well. Using this equivalency, the results of this initial study show that integrating an oximeter into a construction helmet will warn the user of impending carbon monoxide poisoning with a proba- bility greater than 99%.